What to Expect from Grey’s Anatomy Season 21 Episode 16: Amelia Prepares for a High-Risk Surgery
Amelia prepares for a high-risk brain surgery on Grey’s Anatomy Season 21 Episode 16, “Papa Was a Rollin’ Stone.” The patient is a nine-year-old girl, and Amelia seems to be questioning whether it’s a surgery she should even attempt.
This one risky surgery, however, is the only way to save her.
This storyline has Amelia and Monica Beltran working together again, which should be interesting to see. Piper Perabo guest stars as the patient’s mother, and from the looks of the promo video, we’re in for an emotional episode.
Meanwhile, Jo and Link are focused on wedding plans, and Jules and Winston disagree over how to handle a situation with a patient.
Here’s everything you need to know about this episode, including the air date, cast, promo, and how to watch.
Episode Details
- Title: “Papa Was a Rollin’ Stone”
- Air Date: Thursday, May 1st, 2025
- Time: 10/9c
- Network: ABC
How to Watch Grey’s Anatomy Season 21 Episode 16
- Live: ABC at 10/9c
- Streaming: Available next day on Hulu
Grey’s Anatomy Season 21 Episode 16 Description
Amelia undertakes a high-risk brain surgery on a young patient, while Winston and Jules disagree over how to handle their trauma patient’s family. Jo and Link struggle with wedding planning.
Guest Stars & Returning Characters
- Cast: Chandra Wilson, Kevin McKidd, Kim Raver, Caterina Scorsone, James Pickens Jr., Chris Carmack, Camilla Luddington, Anthony Hill, Jason George, Alexis Floyd, Adelaide Kaine, Harry Shum Jr., Nico Terho, Natalie Morales
- Guest Stars: Piper Perabo, Andy Bean, Sophia Kopera, Brady Smith, Gabriel Sousa, Cher Alvarez
Promo & Photos
Check out the photos from Grey’s Anatomy Season 21 Episode 16:
Promo Video:
What are your hopes for this episode of Grey’s Anatomy? Share your thoughts with us in the comments below, and be sure to catch up with our review of Grey’s Anatomy Season 21 Episode 16 right here.
Grey’s Anatomy airs Thursdays at 10/9c on ABC.
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Ashley Bissette Sumerel
Ashley Bissette Sumerel is a television and film critic living in Wilmington, North Carolina. She is editor-in-chief of Tell-Tale TV as well as Eulalie Magazine. Ashley has also written for outlets such as Rolling Stone, Paste Magazine, and Insider. Ashley has been a member of the Critics Choice Association since 2017 and is a Rotten Tomatoes-approved critic. In addition to her work as an editor and critic, Ashley teaches Entertainment Journalism, Composition, and Literature at the University of North Carolina Wilmington.