What to Expect from Grey’s Anatomy Season 22 Episode 5: Sometimes I Feel Like a Motherless Child
Simone treats a patient with a connection to her mother on Grey’s Anatomy Season 22 Episode 5, “Sometimes I Feel Like a Motherless Child.”
In the promo video for the episode (watch it below), Simone greets the patient, then sees that the patient has a photo of her mother. Meanwhile, Jo has a difficult case with a pregnant mother, and Blue and Jules go above and beyond for a patient — possibly more than they should.
Link also seems to be in good spirits, now back to work after recovering from his injuries, and Jo is getting closer to her due date.
Here’s everything you need to know about this episode, including the air date, cast, promo, and how to watch.
Grey’s Anatomy Season 22 Episode 5 Details
- Title: “Sometimes I Feel Like a Motherless Child”
- Air Date: Thursday, November 6th, 2025
- Time: 10/9c
- Network: ABC
- Main cast: Chandra Wilson, Kevin McKidd, Kim Raver, James Pickens Jr., Chris Carmack, Camilla Luddington, Anthony Hill, Jason George, Alexis Floyd, Adelaide Kaine, Harry Shum Jr., Nico Terho, Trevor Jackson, Ellen Pompeo
How to Watch Grey’s Anatomy Season 22 Episode 5
- Live: ABC at 10/9c
- Streaming: Available next day on Hulu
Grey’s Anatomy Season 22 Episode 5 Description
Jo navigates a challenging case with a pregnant mother, while Blue and Jules care for a diabetic patient. Meanwhile, Simone treats a patient with a surprising revelation.
Promo Video:
What are your hopes for this episode of Grey’s Anatomy? Share your thoughts with us in the comments below!
Grey’s Anatomy airs Thursdays at 10/9c on ABC.
Want more from Tell-Tale TV? Subscribe to our newsletter here!
Ashley Bissette Sumerel
Ashley Bissette Sumerel is a television and film critic living in Wilmington, North Carolina. She is editor-in-chief of Tell-Tale TV as well as Eulalie Magazine. Ashley has also written for outlets such as Rolling Stone, Paste Magazine, and Insider. Ashley has been a member of the Critics Choice Association since 2017 and is a Rotten Tomatoes-approved critic. In addition to her work as an editor and critic, Ashley teaches Entertainment Journalism, Composition, and Literature at the University of North Carolina Wilmington.