GREY'S ANATOMY - "Break Down the House" - Meredith and the team are focused on helping Owen's sister after her shocking return, and Amelia faces a conflict over a patient. Meanwhile, Bailey is forced to give Grey Sloan a facelift after the fire, and the doctors are introduced to a few new faces that spice things up around the hospital, on "Grey's Anatomy," THURSDAY, SEPTEMBER 28 (8:00-9:00 p.m. EDT), on The ABC Television Network. (ABC/Derek Johnson) 14 Things We Know About Grey’s Anatomy Season 14 - Part 2 GREY'S ANATOMY - "Break Down the House" - Meredith and the team are focused on helping Owen's sister after her shocking return, and Amelia faces a conflict over a patient. Meanwhile, Bailey is forced to give Grey Sloan a facelift after the fire, and the doctors are introduced to a few new faces that spice things up around the hospital, on "Grey's Anatomy," THURSDAY, SEPTEMBER 28 (8:00-9:00 p.m. EDT), on The ABC Television Network. (ABC/Derek Johnson)

14 Things We Know About Grey’s Anatomy Season 14

Ashley Bissette Sumerel Grey's Anatomy, Previews
7. DeLuca’s Sister
GREY'S ANATOMY - "Back Where You Belong" - Alex returns to the hospital and discovers a lot has changed since he left. Meanwhile, Jo has to make a difficult decision on a case, and Arizona tries to distance herself from Eliza, on "Grey's Anatomy," THURSDAY, FEBRUARY 23 (8:00-9:01 p.m. EST), on the ABC Television Network. (ABC/Eric McCandless)
GREY’S ANATOMY – (ABC/Eric McCandless)GIACOMO GIANNIOTTI

We’ll meet Andrew DeLuca’s sister this season, and she’s going to shake things up a bit. She’ll be played by Stefania Spampinato, who is joining Grey’s Anatomy for a multi-episode arc.

“She has a very interesting and controversial — some would say — profession within the medical field, which makes him uncomfortable,” Giacomo Gianniotti said in an interview.

8. Shocking news
GREY'S ANATOMY - "Get off on the Pain" - Meredith struggles to come up with a new plan for Owen's sister. Jo makes a surprising choice regarding Alex, and Andrew's sister's controversial research leads to a shocking discovery, on "Grey's Anatomy," THURSDAY, SEPTEMBER 28 (9:00-10:00 p.m. EDT), on The ABC Television Network. (ABC/Mitch Haaseth)
GREY’S ANATOMY – (ABC/Mitch Haaseth) CATERINA SCORSONE

Expect shocking news by the end of the two-hour season premiere. Apparently, that news “will really make you question, well, everything.” It wouldn’t be Grey’s Anatomy without an exciting premiere, right?

9. A Jo/Andrew romance might be possible
GREY'S ANATOMY - "You Haven't Done Nothin'" - Believing he is going to jail tomorrow, Alex makes a big decision about his future. While the hospital is overrun with victims of a building collapse, Richard demands answers from Bailey about Eliza's presence at Grey Sloan, on the winter finale of "Grey's Anatomy," THURSDAY, NOVEMBER 17 (8:00-9:00 p.m. EST), on the ABC Television Network. (ABC/Richard Cartwright)
GREY’S ANATOMY – (ABC/Richard Cartwright) CAMILLA LUDDINGTON

Andrew’s timing was pretty terrible with this last season, but apparently, a romance between Jo and Andrew isn’t out of the question. We’ll just have to wait and see what happens.

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10. There may also be room for a Jackson/Maggie romance
GREY'S ANATOMY - "What's Inside" - When Maggie takes on a big case, many of the doctors are worried she's not the right one for the job while Stephanie makes a mistake, treating one of Grey Sloan's own, on "Grey's Anatomy," THURSDAY, APRIL 6 (8:00-9:01 p.m. EDT), on The ABC Television Network. (ABC/Richard Cartwright)
GREY’S ANATOMY – (ABC/Richard Cartwright) JESSE WILLIAMS, KELLY MCCREARY

We saw hints of this last season, and from the looks of the trailer for Grey’s Anatomy Season 14, it seems like a romance between Jackson and Maggie could definitely be on the horizon.

11. Meredith will go through a process of “rediscovery”
GREY'S ANATOMY - "Break Down the House" - Meredith and the team are focused on helping Owen's sister after her shocking return, and Amelia faces a conflict over a patient. Meanwhile, Bailey is forced to give Grey Sloan a facelift after the fire, and the doctors are introduced to a few new faces that spice things up around the hospital, on "Grey's Anatomy," THURSDAY, SEPTEMBER 28 (8:00-9:00 p.m. EDT), on The ABC Television Network. (ABC/Derek Johnson)
GREY’S ANATOMY -(ABC/Derek Johnson) ELLEN POMPEO

With Megan back in the picture for Nathan, Meredith’s world has been turned upside down once again. According to Debbie Allen, that means that Meredith will go through a process of “rediscovery” this season.

12. 300th Episode
GREY'S ANATOMY - "What's Inside" - When Maggie takes on a big case, many of the doctors are worried she's not the right one for the job while Stephanie makes a mistake, treating one of Grey Sloan's own, on "Grey's Anatomy," THURSDAY, APRIL 6 (8:00-9:01 p.m. EDT), on The ABC Television Network. (ABC/Richard Cartwright)
GREY’S ANATOMY – (ABC/Richard Cartwright) KELLY MCCREARY, ELLEN POMPEO, CATERINA SCORSONE

Grey’s Anatomy is achieving a milestone that many shows never come close to. Season 14 will feature the landmark 300th episode (wow!), and “it will be big.”

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Ashley Bissette Sumerel is a television and film critic living in Wilmington, North Carolina. She is editor-in-chief of Tell-Tale TV as well as Eulalie Magazine. Ashley has also written for outlets such as Rolling Stone, Paste Magazine, and Insider. Ashley has been a member of the Critics Choice Association since 2017 and is a Rotten Tomatoes-approved critic. In addition to her work as an editor and critic, Ashley teaches Entertainment Journalism, Composition, and Literature at the University of North Carolina Wilmington.

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