What to Expect from Grey’s Anatomy Season 21 Episode 18: How Do I Live
It’s a dramatic season finale, just like Grey’s Anatomy does best, when a frustrated mother puts everyone in danger. Will Grey’s Anatomy Season 21 Episode 18, “How Do I Live,” end on a cliffhanger? It seems likely.
On the season finale, a patient’s mother takes matters into her own hands by bringing an explosive device into the hospital and threatening Amelia.
Until now, her daughter, Dylan, Amelia’s patient, has been suffering from locked-in syndrome while Amelia waited for the right time to operate again. Meredith is here for this episode as well, and the doctors in immediate danger appear to be Amelia, Lucas, and Simone.
Photos from the episode also suggest that we’ll see more of the situation with Teddy, Owen, and Nora, as Nora’s health declines.
Here’s everything you need to know about this episode, including the air date, cast, promo, and how to watch.
Grey’s Anatomy Season 21 Episode 18 Details
- Title: “How Do I Live”
- Air Date: Thursday, May 15th, 2025
- Time: 10/9c
- Network: ABC
How to Watch Grey’s Anatomy Season 21 Episode 18
- Live: ABC at 10/9c
- Streaming: Available next day on Hulu
Grey’s Anatomy Season 21 Episode 18 Description
The interns are excited to transition to second-year residency; a medical emergency unfolds in the operating room, endangering lives inside the hospital.
Guest Stars & Returning Characters
- Cast: Chandra Wilson, Kevin McKidd, Kim Raver, Caterina Scorsone, James Pickens Jr., Chris Carmack, Camilla Luddington, Anthony Hill, Jason George, Alexis Floyd, Adelaide Kaine, Harry Shum Jr., Nico Terho, Natalie Morales, Ellen Pompeo
- Guest Stars: Piper Perabo, Floriana Limia, Jacqueline Mazarella
- Notable Returns: Ellen Pompeo as Meredith Grey
Promo & Photos
Check out the photos from Grey’s Anatomy Season 21 Episode 18:
Promo Video:
What are your hopes for this episode of Grey’s Anatomy? Share your thoughts with us in the comments below, and be sure to catch up with our review of Grey’s Anatomy Season 21 Episode 17 right here.
Grey’s Anatomy airs Thursdays at 10/9c on ABC.
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Ashley Bissette Sumerel
Ashley Bissette Sumerel is a television and film critic living in Wilmington, North Carolina. She is editor-in-chief of Tell-Tale TV as well as Eulalie Magazine. Ashley has also written for outlets such as Rolling Stone, Paste Magazine, and Insider. Ashley has been a member of the Critics Choice Association since 2017 and is a Rotten Tomatoes-approved critic. In addition to her work as an editor and critic, Ashley teaches Entertainment Journalism, Composition, and Literature at the University of North Carolina Wilmington.